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Why did my good quality embryo not implant?


When you are using donor eggs to build your family, you have most probably spent hours, if not weeks or months, carefully going through donor profiles to find the donor that most suits your family’s needs. This donor will be a young, healthy woman, carefully screened with rigorous psychological, physical, gynecological and genetic screening. The donor will have undergone a controlled ovarian stimulation to obtain the eggs that you will then use for fertilization to become your embryos.

It is normal to expect that these eggs will be of the best quality and therefore the embryos that are produced from them to be of the best quality for implantation and give the desired pregnancy. However, not all good quality embryos will implant into the uterus. One of the most important factors in embryo implantation is the contact with and state of the endometrium; the layer of tissue that lines the interior of the uterine cavity where the embryo attaches to initiate gestation.

When you source your donor eggs from OvobankID, they will arrive at your clinic in a vitrified (frozen) form. On the day of fertilization, your clinic will thaw them in the laboratory and they will be fertilized with sperm (partner, own or donor sperm as required). The resulting embryos are cultured in the laboratory until they reach the blastocyst stage (5 days). During this process, embryologists analyze them and classify them according to their quality.

Embryos are classified using such criteria as: the number of cells and their symmetry, the percentage and type cell fragmentation and the rate of division of the embryo, among others. The grading system of A – D can be explained as follows:

Embryo A: optimal quality and maximum implantation capacity

Embryo B: good quality and implantation capacity

Embryo C: medium quality and implantation capacity

Embryo D: low quality and implantation capacity

In general, embryologists choose embryos graded as A or B, since they are the most likely to implant and thus achieve the desired pregnancy. If, as on some occasions, no good-quality embryos are obtained, a medium-quality embryo may be transferred.  Any surplus embryos can be frozen (vitrified) for later attempts.

what is meant by implantion failure?

If pregnancy has not been achieved after three or more cycles in which good-quality embryos have been transferred, it is considered to be implantation failure. When faced with implantation failure it is vital to investigate the root of the problem in order to solve it before trying again, with the aim of successful pregnancy as soon as possible.

WHY do i fail to get pregnant?

The most common reasons for implantation failure and failure to achieve pregnancy are frequently due to embryonic and/or uterine causes. However, other factors can also be involved such as infertility of unknown origin, which can be very difficult and complicated to diagnose.

Implantation failure due to embryonic causes with an embryo that appears to be of good quality can be due to genetic alterations, for example, having an incorrect chromosomal load. This can lead to miscarriage. The use of Preimplantation Genetic Diagnosis (PGD) to study the embryo’s genetic complement (from an embryo biopsy) can be done to try and avoid transferring any embryos with genetic abnormalities.

If the cause for the implantation failure lies with the uterus, it could be because the endometrium is not in its optimal receptive state at the time of the embryo transfer. It is possible to freeze the embryos and perform tests such as the endometrial receptivity array (ERA) to study when the endometrium is in the best condition to perform embryo transfer, and then program the future transfers accordingly.

At OvobankID we want to help you in bringing home a baby, and strive to provide the best service and quality, with the shortest wait possible and competitive prices that help meet your family building budget. For more information on our batches of frozen donor eggs, our database of generous and ethically-treated donors, our clinical pregnancy guarantee programs or to speak to one of our friendly and knowledgeable country-specific advisors about how we can help you – get in touch today using our contact form or by email:

We look forward to hearing from you!

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